Destroy All Humans! 2 is a 2006 action-adventure video game developed by Pandemic Studios and published by THQ for PlayStation 2 and Xbox. The game is the sequel to Destroy All Humans! and the second installment in the Destroy All Humans! franchise. It also marks the final game in the series to be developed by Pandemic Studios, as the company was later acquired by Electronic Arts in 2007. A remake of the game, titled Destroy All Humans! 2: Reprobed, was initially released in August 2022.

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